:root {
  --color-petrol-900: #173a3d;
  --color-teal-700: #1f625d;
  --color-ivory-050: #faf8f4;
  --color-white: #ffffff;
  --color-sage-100: #ddece5;
  --color-sage-050: #edf5f1;
  --color-lavender-100: #eee8f3;
  --color-coral-700: #b44e5c;
  --color-slate-600: #526a6b;
  --color-blue-700: #1a5b72;
  --color-border-200: #d9e2dd;
  --color-border-500: #718785;

  --font-sans: system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;
  --font-size-label: 0.8125rem;
  --font-size-caption: 0.9375rem;
  --font-size-body: 1rem;
  --font-size-lead: clamp(1.125rem, 1.05rem + 0.35vw, 1.25rem);
  --font-size-h3: clamp(1.25rem, 1.15rem + 0.5vw, 1.5rem);
  --font-size-h2: clamp(1.625rem, 1.35rem + 1.2vw, 2.25rem);
  --font-size-h1: clamp(2rem, 1.55rem + 2.2vw, 3.5rem);
  --line-height-body: 1.65;
  --line-height-heading: 1.15;

  --space-1: 0.25rem;
  --space-2: 0.5rem;
  --space-3: 0.75rem;
  --space-4: 1rem;
  --space-5: 1.5rem;
  --space-6: 2rem;
  --space-7: 3rem;
  --space-8: 4rem;
  --space-9: 6rem;

  --container-max: 75rem;
  --copy-max: 68ch;
  --lead-max: 60ch;
  --page-gutter: clamp(1rem, 4vw, 2rem);
  --section-space: clamp(3.5rem, 8vw, 6rem);
  --grid-gap: clamp(1rem, 2.5vw, 1.5rem);
  --target-min: 2.75rem;

  --radius-small: 0.5rem;
  --radius-medium: 0.75rem;
  --radius-large: 1rem;
  --radius-panel: 1.25rem;
  --radius-pill: 999px;
}

*,
*::before,
*::after {
  box-sizing: border-box;
}

html {
  color-scheme: light;
  scroll-padding-top: 1rem;
}

body {
  margin: 0;
  background: var(--color-ivory-050);
  color: var(--color-petrol-900);
  font-family: var(--font-sans);
  font-size: var(--font-size-body);
  line-height: var(--line-height-body);
}

img,
svg {
  display: block;
  max-width: 100%;
}

h1,
h2,
h3,
p,
ul,
ol,
figure {
  margin-top: 0;
}

h1,
h2,
h3 {
  color: var(--color-petrol-900);
  font-weight: 700;
  letter-spacing: -0.025em;
  line-height: var(--line-height-heading);
  text-wrap: balance;
}

h1 {
  max-width: 19ch;
  margin-bottom: var(--space-5);
  font-size: var(--font-size-h1);
}

h2 {
  margin-bottom: var(--space-4);
  font-size: var(--font-size-h2);
}

h3 {
  margin-bottom: var(--space-3);
  font-size: var(--font-size-h3);
}

p,
li {
  text-wrap: pretty;
}

p:last-child,
li:last-child {
  margin-bottom: 0;
}

a {
  color: var(--color-blue-700);
  text-decoration-line: underline;
  text-decoration-thickness: 0.08em;
  text-underline-offset: 0.2em;
}

a:hover {
  text-decoration-thickness: 0.14em;
}

a:focus-visible {
  border-radius: 0.15rem;
  outline: 3px solid var(--color-blue-700);
  outline-offset: 3px;
}

.skip-link {
  position: fixed;
  z-index: 100;
  top: var(--space-3);
  left: var(--space-3);
  padding: var(--space-3) var(--space-4);
  transform: translateY(-180%);
  border-radius: var(--radius-small);
  background: var(--color-white);
  color: var(--color-petrol-900);
  font-weight: 700;
}

.skip-link:focus {
  transform: translateY(0);
}

.site-shell {
  width: min(100% - (2 * var(--page-gutter)), var(--container-max));
  margin-inline: auto;
}

.reading-column,
.section-heading {
  max-width: var(--copy-max);
}

.site-header {
  border-bottom: 1px solid var(--color-border-200);
  background: var(--color-white);
}

.header-layout {
  display: grid;
  gap: var(--space-4);
  padding-block: var(--space-4);
}

.site-brand {
  display: inline-flex;
  width: fit-content;
  min-height: var(--target-min);
  align-items: center;
  text-decoration: none;
}

.site-brand-logo {
  display: block;
  width: 13rem;
  max-width: 100%;
  height: auto;
}

.primary-navigation ul,
.site-footer ul {
  margin: 0;
  padding: 0;
  list-style: none;
}

.primary-navigation ul {
  display: flex;
  flex-wrap: wrap;
  gap: var(--space-2) var(--space-4);
}

.primary-navigation a {
  display: inline-flex;
  min-height: var(--target-min);
  align-items: center;
  color: var(--color-petrol-900);
  font-size: 0.9375rem;
  font-weight: 600;
  text-decoration: none;
}

.primary-navigation a:hover {
  text-decoration: underline;
  text-underline-offset: 0.25em;
}

.primary-navigation a[aria-current="page"] {
  text-decoration: underline;
  text-decoration-thickness: 0.14em;
  text-underline-offset: 0.3em;
}

.hero-section {
  padding-block: clamp(3.5rem, 9vw, 7rem);
  background: var(--color-ivory-050);
}

.hero-layout {
  max-width: calc(var(--lead-max) + (2 * var(--page-gutter)));
}

.hero-summary,
.hero-support {
  max-width: var(--lead-max);
}

.hero-summary {
  font-size: var(--font-size-lead);
}

.hero-support {
  color: var(--color-slate-600);
}

.section-kicker {
  margin-bottom: var(--space-3);
  color: var(--color-teal-700);
  font-size: var(--font-size-label);
  font-weight: 700;
  letter-spacing: 0.08em;
  text-transform: uppercase;
}

.action-row,
.link-row {
  display: flex;
  flex-direction: column;
  align-items: stretch;
  gap: var(--space-3);
  margin-top: var(--space-6);
}

.primary-action,
.secondary-action {
  display: inline-flex;
  min-height: 3rem;
  align-items: center;
  justify-content: center;
  padding: 0.75rem 1.25rem;
  border: 2px solid var(--color-teal-700);
  border-radius: var(--radius-pill);
  font-weight: 700;
  line-height: 1.25;
  text-align: center;
  text-decoration: none;
}

.primary-action {
  background: var(--color-teal-700);
  color: var(--color-white);
}

.secondary-action {
  background: var(--color-white);
  color: var(--color-petrol-900);
}

.primary-action:hover {
  background: var(--color-petrol-900);
  border-color: var(--color-petrol-900);
}

.secondary-action:hover {
  background: var(--color-sage-050);
}

.primary-action:focus-visible,
.secondary-action:focus-visible {
  outline-offset: 4px;
}

.medical-note,
.context-note {
  max-width: var(--copy-max);
  padding: var(--space-4);
  border-left: 4px solid var(--color-teal-700);
  background: var(--color-white);
}

.medical-note {
  margin-top: var(--space-6);
  margin-bottom: 0;
}

.content-section {
  padding-block: var(--section-space);
}

.section-heading {
  margin-bottom: var(--space-6);
}

.section-heading > :last-child {
  margin-bottom: 0;
}

.start-section {
  background: var(--color-petrol-900);
  color: var(--color-white);
}

.start-section h2,
.start-section .section-kicker,
.start-section .section-heading p {
  color: var(--color-white);
}

.path-grid {
  display: grid;
  gap: var(--space-3);
  margin: 0;
  padding: 0;
  list-style: none;
}

.path-grid a {
  display: grid;
  min-height: 100%;
  align-content: space-between;
  gap: var(--space-6);
  padding: var(--space-5);
  border: 1px solid transparent;
  border-radius: var(--radius-medium);
  background: var(--color-white);
  color: var(--color-petrol-900);
  font-weight: 700;
  line-height: 1.35;
  text-decoration: none;
}

.path-grid a::after {
  content: "Acessar →";
  color: var(--color-blue-700);
  font-size: var(--font-size-caption);
  font-weight: 700;
}

.path-grid a:hover {
  border-color: var(--color-border-500);
  background: var(--color-sage-050);
}

.path-grid a:focus-visible,
.site-footer a:focus-visible {
  outline-color: var(--color-ivory-050);
}

.path-grid span,
.card-index {
  display: block;
  color: var(--color-slate-600);
  font-size: var(--font-size-label);
  font-weight: 700;
  letter-spacing: 0.08em;
}

.split-layout,
.compact-split {
  display: grid;
  gap: var(--space-7);
}

.overview-section,
.diagnosis-section,
.appointment-section,
.questions-section {
  background: var(--color-white);
}

.educational-figure {
  max-width: 30rem;
  margin: 0;
}

.educational-figure picture,
.educational-figure img {
  display: block;
  width: 100%;
  height: auto;
}

.educational-figure picture {
  overflow: hidden;
  border-radius: var(--radius-large);
}

.educational-figure figcaption {
  margin-top: var(--space-3);
  color: var(--color-slate-600);
  font-size: var(--font-size-caption);
}

.text-link {
  display: inline-flex;
  min-height: var(--target-min);
  align-items: center;
  font-weight: 700;
}

.signs-section,
.treatment-section {
  background: var(--color-sage-100);
}

.signs-grid,
.check-list,
.evidence-grid ul {
  padding-left: 1.25rem;
}

.signs-grid {
  display: grid;
  gap: var(--space-3) var(--space-7);
  margin-bottom: var(--space-6);
}

.signs-grid li::marker,
.check-list li::marker,
.evidence-grid li::marker {
  color: var(--color-teal-700);
}

.process-list {
  display: grid;
  gap: var(--space-4);
  margin: 0 0 var(--space-6);
  padding: 0;
  list-style: none;
  counter-reset: process;
}

.process-list li {
  display: grid;
  grid-template-columns: auto 1fr;
  gap: var(--space-4);
  padding: var(--space-5);
  border: 1px solid var(--color-border-200);
  border-radius: var(--radius-medium);
  background: var(--color-ivory-050);
}

.process-list > li > span {
  display: inline-grid;
  width: var(--target-min);
  height: var(--target-min);
  place-items: center;
  border-radius: 50%;
  background: var(--color-petrol-900);
  color: var(--color-white);
  font-weight: 700;
}

.process-list p {
  margin-bottom: 0;
}

.process-list .process-title {
  margin-bottom: var(--space-2);
  font-size: 1.125rem;
  font-weight: 700;
  line-height: 1.25;
}

.urgent-section {
  padding-block: var(--space-7);
  background: var(--color-white);
}

.urgent-layout {
  display: grid;
  gap: var(--space-5);
  padding: var(--space-5);
  border: 1px solid var(--color-border-200);
  border-left: 5px solid var(--color-coral-700);
  border-radius: 0 var(--radius-medium) var(--radius-medium) 0;
}

.urgent-layout h2 {
  font-size: clamp(1.5rem, 1.3rem + 0.9vw, 2rem);
}

.comparison-section,
.evidence-section {
  background: var(--color-lavender-100);
}

.comparison-grid,
.treatment-grid,
.evidence-grid {
  display: grid;
  gap: var(--grid-gap);
}

.comparison-grid > div,
.treatment-grid article,
.evidence-grid > section {
  padding: var(--space-5);
  border: 1px solid var(--color-border-200);
  border-radius: var(--radius-large);
  background: var(--color-white);
}

.comparison-grid {
  margin-bottom: var(--space-6);
}

.comparison-grid dt {
  margin-bottom: var(--space-3);
  font-size: var(--font-size-h3);
  font-weight: 700;
  letter-spacing: -0.025em;
  line-height: var(--line-height-heading);
}

.comparison-grid dd {
  margin: 0;
}

.stages-section {
  background: var(--color-ivory-050);
}

.treatment-grid {
  margin-bottom: var(--space-6);
}

.treatment-grid article {
  display: flex;
  flex-direction: column;
}

.treatment-grid .text-link {
  margin-top: auto;
}

.treatment-section > .site-shell > .primary-action {
  margin-block: var(--space-4) var(--space-5);
}

.check-list {
  display: grid;
  align-content: start;
  gap: var(--space-3);
  margin-bottom: 0;
}

.evidence-grid > section:first-child {
  background: var(--color-sage-100);
}

.evidence-grid > section:last-child {
  background: var(--color-lavender-100);
}

.evidence-grid {
  margin-bottom: var(--space-6);
}

.questions-list article {
  padding-block: var(--space-5);
  border-top: 1px solid var(--color-border-200);
}

.questions-list article:last-child {
  border-bottom: 1px solid var(--color-border-200);
}

.questions-list h3 {
  max-width: 52ch;
}

.questions-list p {
  max-width: var(--copy-max);
}

.content-section.source-footer,
.article-section.source-footer {
  padding-block: var(--space-5);
  border-top: 1px solid var(--color-border-200);
  background: var(--color-white);
}

.source-disclosure {
  max-width: var(--copy-max);
  color: var(--color-slate-600);
  font-size: var(--font-size-caption);
}

.source-disclosure summary {
  padding-block: 0.625rem;
  cursor: pointer;
  font-weight: 600;
}

.source-disclosure summary::marker {
  color: var(--color-teal-700);
}

.source-disclosure summary:focus-visible {
  border-radius: var(--radius-small);
  outline: 3px solid var(--color-blue-700);
  outline-offset: 3px;
}

.source-disclosure__content {
  padding-top: var(--space-3);
}

.reference-list {
  display: grid;
  gap: var(--space-3);
  max-width: var(--copy-max);
  margin: 0;
  padding: 0;
  list-style: none;
}

.reference-list > li {
  padding-top: var(--space-3);
  border-top: 1px solid var(--color-border-200);
  overflow-wrap: anywhere;
}

.reference-list > li:first-child {
  padding-top: 0;
  border-top: 0;
}

.reference-list a {
  font-weight: 600;
}

.reference-list cite {
  font-style: normal;
}

.reference-additional-links {
  display: grid;
  gap: var(--space-2);
  margin: var(--space-2) 0 0;
  padding-left: 1.25rem;
}

.reference-additional-links a {
  font-weight: 400;
}

.source-library-link {
  display: inline-flex;
  min-height: var(--target-min);
  align-items: center;
  margin-top: var(--space-4);
  font-weight: 600;
}

.source-group + .source-group {
  margin-top: var(--space-7);
}

.source-group h3 {
  max-width: var(--copy-max);
}

.reference-list--library {
  max-width: 75rem;
  gap: var(--space-4);
  font-size: var(--font-size-body);
}

.reference-list--library > li {
  padding-top: var(--space-4);
}

.reference-list--library > li:first-child {
  padding-top: 0;
}

.breadcrumb-navigation {
  padding-top: var(--space-5);
}

.breadcrumb-list {
  display: flex;
  flex-wrap: wrap;
  gap: var(--space-2);
  margin: 0;
  padding: 0;
  color: var(--color-slate-600);
  font-size: var(--font-size-caption);
  list-style: none;
}

.breadcrumb-list li {
  display: inline-flex;
  align-items: center;
  gap: var(--space-2);
}

.breadcrumb-list li + li::before {
  content: "/";
  color: var(--color-border-500);
}

.breadcrumb-list a {
  display: inline-flex;
  min-height: var(--target-min);
  align-items: center;
}

.article-hero {
  padding-bottom: clamp(3rem, 7vw, 5rem);
  background: var(--color-white);
}

.article-hero-content {
  padding-top: clamp(2rem, 5vw, 4rem);
}

.article-lead {
  max-width: var(--lead-max);
  font-size: var(--font-size-lead);
}

.article-intro-note {
  max-width: var(--copy-max);
  margin-top: var(--space-6);
  padding: var(--space-5);
  border: 1px solid var(--color-border-200);
  border-left: 5px solid var(--color-teal-700);
  border-radius: 0 var(--radius-medium) var(--radius-medium) 0;
  background: var(--color-sage-050);
}

.article-section {
  padding-block: clamp(3rem, 7vw, 5rem);
}

.article-section--sage {
  background: var(--color-sage-100);
}

.article-section--lavender {
  background: var(--color-lavender-100);
}

.article-copy {
  max-width: var(--copy-max);
}

.article-copy > * + h2,
.article-copy > * + h3 {
  margin-top: var(--space-7);
}

.article-copy > ul,
.article-copy > ol,
.key-point-list,
.question-list {
  padding-left: 1.25rem;
}

.article-copy li + li,
.key-point-list li + li,
.question-list li + li {
  margin-top: var(--space-3);
}

.article-card-grid,
.condition-card-grid,
.related-page-grid {
  display: grid;
  gap: var(--grid-gap);
}

.article-card,
.condition-card,
.related-page-grid article {
  padding: var(--space-5);
  border: 1px solid var(--color-border-200);
  border-radius: var(--radius-large);
  background: var(--color-white);
}

.article-card > :last-child,
.condition-card > :last-child,
.related-page-grid article > :last-child {
  margin-bottom: 0;
}

.condition-card dl {
  margin-bottom: 0;
}

.condition-card dt {
  margin-top: var(--space-5);
  color: var(--color-petrol-900);
  font-weight: 700;
}

.condition-card dt:first-child {
  margin-top: 0;
}

.condition-card dd {
  margin: var(--space-1) 0 0;
}

.evidence-callout,
.safety-callout {
  max-width: var(--copy-max);
  padding: var(--space-5);
  border-radius: var(--radius-medium);
}

.evidence-callout {
  border: 1px solid var(--color-border-500);
  background: var(--color-white);
}

.safety-callout {
  border: 1px solid var(--color-border-200);
  border-left: 5px solid var(--color-coral-700);
  background: var(--color-white);
}

.evidence-callout h2,
.evidence-callout h3,
.safety-callout h2,
.safety-callout h3 {
  font-size: var(--font-size-h3);
}

.article-figure-row {
  display: grid;
  gap: var(--space-7);
}

.related-page-grid article {
  display: flex;
  flex-direction: column;
}

.related-page-grid .text-link {
  margin-top: auto;
}

.article-sources {
  background: var(--color-white);
}

.error-section {
  min-height: 60vh;
}

.error-section .primary-action {
  margin-top: var(--space-4);
}

.site-footer {
  padding-block: var(--space-8);
  background: var(--color-petrol-900);
  color: var(--color-ivory-050);
}

.footer-layout {
  display: grid;
  gap: var(--space-7);
}

.footer-brand,
.site-footer h2,
.site-footer a {
  color: var(--color-ivory-050);
}

.site-footer h2 {
  margin-bottom: var(--space-4);
  font-size: 1rem;
  letter-spacing: 0;
}

.footer-intro {
  max-width: 34rem;
}

.footer-intro p {
  margin-top: var(--space-4);
}

.site-footer li + li {
  margin-top: var(--space-2);
}

.site-footer nav a {
  display: inline-flex;
  min-height: var(--target-min);
  align-items: center;
}

@media (min-width: 36rem) {
  .action-row,
  .link-row {
    flex-direction: row;
    align-items: center;
    flex-wrap: wrap;
  }

  .primary-action,
  .secondary-action {
    width: auto;
  }

  .path-grid {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }
}

@media (min-width: 48rem) {
  .header-layout {
    grid-template-columns: auto 1fr;
    align-items: center;
  }

  .primary-navigation ul {
    justify-content: flex-end;
  }

  .split-layout,
  .compact-split,
  .urgent-layout {
    grid-template-columns: minmax(0, 1fr) minmax(0, 1fr);
    align-items: start;
  }

  .signs-grid,
  .process-list,
  .treatment-grid,
  .evidence-grid {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }

  .comparison-grid {
    grid-template-columns: repeat(3, minmax(0, 1fr));
  }

  .article-card-grid,
  .related-page-grid {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }

  .article-figure-row {
    grid-template-columns: minmax(0, 1.2fr) minmax(18rem, 0.8fr);
    align-items: start;
  }

  .footer-layout {
    grid-template-columns: minmax(0, 2fr) minmax(10rem, 1fr) minmax(10rem, 1fr);
  }

  .full-span {
    grid-column: 1 / -1;
  }
}

@media (min-width: 64rem) {
  .path-grid {
    grid-template-columns: repeat(5, minmax(0, 1fr));
  }

  .treatment-grid {
    grid-template-columns: repeat(6, minmax(0, 1fr));
  }

  .treatment-grid article {
    grid-column: span 2;
  }

  .treatment-grid article:nth-last-child(-n + 2) {
    grid-column: span 3;
  }

  .process-list {
    grid-template-columns: repeat(4, minmax(0, 1fr));
  }

  .condition-card-grid {
    grid-template-columns: repeat(3, minmax(0, 1fr));
  }

  .process-list li {
    grid-template-columns: 1fr;
  }
}

@media (forced-colors: active) {
  .primary-action,
  .secondary-action,
  .source-disclosure summary,
  .process-list > li > span {
    border: 2px solid currentColor;
  }
}